Research indicates that certain RAR subtypes, specifically RAR
Interpretable machine learning analysis of clinicopathological ... - PMC 10273 rar
, play a critical role in controlling cell death complexes, making them potential targets for cancer therapies. For example, combinations of retinoic acid and drugs like metformin are being studied to increase anti-tumor effects in brain cancers like glioblastoma. Retinoids that bind to RARs are widely used
Retinoids that bind to RARs are widely used in topical formulations to treat skin conditions and are studied for their chemopreventive properties against oral malignancies. Potential Technical Interpretation Research and Medical Significance
Retinoic Acid Receptors (RARs) are a type of nuclear receptor activated by both all-trans retinoic acid and 9-cis retinoic acid. They act as transcription factors, meaning they bind to specific DNA sequences to control the expression of genes critical for cell growth, differentiation, and cell death. Research and Medical Significance