: Tim Goodman (Justice Smith), a 21-year-old insurance agent, travels to Ryme City after the mysterious disappearance and presumed death of his father, Harry.

: Tim encounters a Pikachu (voiced by Ryan Reynolds) who was his father's partner. Uniquely, Tim can understand exactly what this Pikachu is saying, though others only hear "Pika-Pika".

The story is set in , a unique metropolis where humans and Pokémon coexist as equals without Poké Balls or competitive battles.