Neurons regulate glycolysis dynamically in response to metabolic stress.
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-related research (such as cell-level studies or related data). GIGP-40.mp4
GDGP becomes critical during conditions of transient hypoxia or mitochondrial dysfunction, acting as a backup fuel source to sustain synaptic vesicle recycling.
Glycogen supports glycolytic plasticity in neurons - PMC - NIH Glycogen supports glycolytic plasticity in neurons - PMC
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Glycogen serves as a direct fuel source to sustain glycolytic plasticity and synaptic function in vivo. The inability to utilize GDGP is associated with deficiencies in synaptic vesicle recycling during hypoxia. This paper explores the role of glycogen as
This paper explores the role of glycogen as a metabolic fuel source within neurons, specifically focusing on Glycogen-Dependent Glycolytic Plasticity (GDGP). Recent studies using sensors like HYlight in models such as Caenorhabditis elegans have identified that neurons can utilize glycogen to regulate glycolytic states during periods of high activity or transient hypoxia. This study highlights the essential role of PYGL-1, an ortholog of human glycogen phosphorylase, in sustaining this plasticity. Introduction