File: | Akt_collection_compressed_2022-11-20.zip ...

Somatic mutations in AKT, particularly the , alter the PH domain structure, leading to constitutive membrane localization and hyperactivation of downstream effectors like mTOR and ERK1/2. This promotes uncontrolled proliferation and resistance to apoptosis. AKT1 Transcriptomic Landscape in Breast Cancer Cells - MDPI

AKT (Protein Kinase B) is a critical serine-threonine kinase existing in three isoforms (AKT1, AKT2, AKT3) that integrates signals from the PI3K pathway to regulate metabolism, survival, and proliferation. This paper analyzes the distinct and overlapping roles of these isoforms using transcriptomic landscapes and multi-omic profiling. We demonstrate that while AKT1 primarily drives somatic growth, AKT2 is essential for glucose metabolism, and AKT3 influences neuronal development. Furthermore, we explore how aberrant activation via somatic mutations, such as AKT1 (E17K), contributes to tumorigenesis in breast and colorectal cancers. 1. Introduction File: AKT_collection_compressed_2022-11-20.zip ...

Research indicates that AKT isoforms are not functionally redundant: Somatic mutations in AKT, particularly the , alter

: Predominantly expressed in the brain, where it regulates organ size and neurodevelopment. 3. Pathological Dysregulation 3.1 Cancer This paper analyzes the distinct and overlapping roles

We found that changes in the cellular levels of AKT1 lead to changes in the levels of a set of differentially expressed genes and, Akt isoforms in the immune system - Frontiers

Multi-Isoform AKT Signaling: A Systems-Level Analysis of Cellular Homeostasis and Oncogenesis