Don't rush the main quest. After leaving Vault 111, head to and Concord , but then focus on building a small base.
Join the Railroad early just long enough to do a few "PAM" missions. This unlocks the ability to put armor stats on regular clothes (like suits or fatigues), allowing you to wear armor over them for double protection.
Decide between the Brotherhood of Steel , The Railroad , The Minutemen , or The Institute . Don't rush the main quest
Even in the GOTY edition, the engine can be "cranky." Use manual saves before entering the Glowing Sea.
You can become the Overboss of three Raider gangs. This unlocks the ability to put armor stats
Once you feel sturdy, head to the Northeast corner of the map to start .
Since you are on v1.10.163, ensure you use the "Mod Manager" if you want to fix the "Boston Gray Screen/Crash" area, which is notorious in this version near Faneuil Hall. Essential "Survivor" Tips for your Version: You can become the Overboss of three Raider gangs
With your DLC gear and robot armies, return to the main quest.