C4.zip

: Enrichment of dilute samples to ensure they are within the detection range of highly sensitive instruments. Role in Mass Spectrometry

: Best for proteins > 10 kDa and highly hydrophobic peptides. c4.zip

This technology has been instrumental in recent studies, including identifying SARS-CoV-2 protease cleavage sites and characterizing human cannabinoid receptors. : Enrichment of dilute samples to ensure they

Expression, Purification and Characterization of the Human ... - Nature Expression, Purification and Characterization of the Human

A C4 ZipTip is a standard pipette tip containing a microscopic bed of resin fixed at its distal end. Unlike C18 resins, which are used for smaller peptides, the C4 resin is optimized for larger, more hydrophobic molecules like proteins and large polypeptides. Primary Uses in Research Researchers use these tools for two main reasons:

: Contaminants are washed away with a dilute acid, such as trifluoroacetic acid (TFA) .